Type 2 Diabetes: You Can Reverse It

Half of the people with diabetes don’t even know it (1). This is very dangerous. If left unchecked, diabetes can be fatal. Diabetes is a progressive, debilitating disease that can result in blindness, nerve damage that leads to limb amputation, and finally death.

Image: World Diabetes Atlas, 2021

So, what is T2D, and what can we do to prevent it? To fully understand what goes wrong in the human body to cause diabetes, first, we need to understand normal glucose metabolism.

Normal glucose metabolism

The human body loves glucose! Glucose is the body’s preferred fuel source. Every time we eat food, the body breaks down the carbohydrates into individual glucose molecules and uses them for energy. If we don’t eat any carbohydrates, the body will use glycogen, which is a form of glucose stored in the liver and muscles. If the body is depleted of glycogen, it will convert fat and muscle tissue to use as fuel instead.

After digestion, glucose enters the bloodstream. This rise in blood glucose signals the beta cells of the pancreas to produce the hormone, insulin.

Insulin is like a key to a lock. Its job is to help the glucose enter the body’s cells so that it can be converted to energy. Only the insulin key can open the door of the cell to allow the glucose inside. Some glucose is also absorbed by the liver to create glycogen, some is stored in the muscles or used by the muscles for energy, and some is converted to fatty acids and stored as triglycerides in fat cells.

Progression of Type 2 Diabetes

At the same time, fat accumulation within the pancreas can cause a progressive decrease in insulin production. It’s a double-edged sword: there’s not enough insulin to clear the glucose, and the insulin that is in the blood, is not doing its job correctly.

Extended periods of high concentrations of blood glucose can cause hypertension (high blood pressure), retinopathy (eye disease) nephropathy (kidney disease), cardiovascular disease and neuropathy (nerve damage)(2).

What causes diabetes?

Obesity is one of the main precursors to insulin resistance and T2D. About 90% of people with T2D are overweight (3). Being obese, with a body mass index (BMI) of >35 kg/m2 increases the risk of developing diabetes over 10 years by 80 times. Compared to people of a healthy weight, people with obesity have increased insulin resistance, increased liver glucose production, and increased circulating free fatty acids (FFA). Obesity causes chronic inflammation, that can lead to insulin resistance and beta cell dysfunction (4).

Genetic factors can play a role in the development of T2D (5). Diabetes is more prevalent in Pacific Islanders, African Americans, Hispanic and Asian populations than in Caucasians. Whilst only 10-15% of T2D is attributed to genetic influences (6), having a genetic predisposition for diabetes does not dictate our future. How we live our lives is far more important.

How do we avoid developing diabetes?

The key to weight loss is reducing caloric intake. In a 2018 UK study assessing the effect of weight loss on patients with T2D, 86% of participants who lost 15 kg achieved full remission of their diabetes (9). None of the participants who gained weight achieved remission.

Losing weight is a complex and often stressful process, but it doesn’t have to be that way. Removing high-calorie-dense foods such as ultra-processed foods, fried foods and foods containing animal products from our diets can dramatically lower the number of calories we consume.

The Solution

Cooking styles also influence the calorie density of our diets. Frying and sauteing in oil can add many hundreds of calories to an otherwise healthy diet. Boiling, steaming and air-frying allow you to eat as much as you like without the added fat calories. Air-fried potatoes taste just as good as oil-fried potatoes and contain a fraction of the calories.

Practical tips

• Aim to keep your weight in the normal range.
• See your primary care physician and check your blood glucose levels regularly.
• For a healthy way to reduce calorie density and lose weight, switch high-calorie processed foods and animal products out for low-calorie plant foods.
• Download our factsheet on Type 2 Diabetes for patients for more practical tips on whole food plant-based eating for diabetes management. 

The bottom line

Changing the way you eat can be challenging. Instead of changing everything at once, look for ways to make healthy choices. Add more veggies to your plate. Choose fruit for snacks. Cook more at home. Small actions done consistently can add up to big changes.

Quiz Questions

Good luck!